---
title: Why Reproducibility Still Breaks in Biopharma Labs and How to Fix It
description: See how irreproducible methods drive hidden lab costs, and how visual training can improve consistency, reduce variability, and support more reliable R&D.
---

[JoVE BLOG | JoVE](https://blog.jove.com)

# [Why Reproducibility Still Breaks in Biopharma Labs and How to Fix It](https://blog.jove.com/why-reproducibility-still-breaks-and-how-to-fix-it-biopharma-2026)

 Written by [Ellen Ovenden, MSc & Rucha Joshi](https://blog.jove.com/author/ellen-ovenden-msc-rucha-joshi) | Apr 28, 2026 6:54:19 PM

**More than half** of US preclinical animal-model studies are considered **irreproducible**, with an estimated annual cost of **$28–40 billion**.1,2

While protocols may be clearly written, reproducibility often breaks down in execution. Small variations in technique, timing, and setup can lead to inconsistent results across teams and sites.

[View full post](https://blog.jove.com/why-reproducibility-still-breaks-and-how-to-fix-it-biopharma-2026)

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